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Ingenuity Pathway Analysis showed that compared to vehicle treatment, mGIPR-Ab/P1 treatment of Gipr fl/fl and Glp1r fl/fl mice resulted in negative enrichment in cell cycle regulation, cholesterol biosynthesis, extracellular matrix (ECM) and collagen organization, and immune response and inflammation pathways in both WAT and liver (Fig

2025 Apr;242(4):71724

A GLP-1-only plan targets one pathway related to appetite and digestion, while GIP + GLP-1 targets two pathways that may enhance metabolic response and insulin sensitivity for some people